PEG-20M毛细管柱测定 注射用头孢噻肟钠中2乙基己酸

注射用头孢噻肟钠中2乙基己酸，芝麻香白酒，3-甲硫基丙醇，室内空气，焦炉煤气，炼厂气，天然气，变压器油，多氯联苯，植物油，6号溶剂残留，裂解进样器，增塑剂，塑化剂，氨水

注射用头孢噻肟钠中2乙基己酸
注射用头孢噻肟钠中2乙基己酸 详细信息：

名称：毛细管柱
固定液：聚乙二醇
规格：30m*0.25mm*0.25um
型号：PEG-20M

注射用头孢噻肟钠为第三代半合成头孢菌素，抗菌谱比头孢呋肟更广，适用于敏感细菌所致的肺炎及其他下呼吸道感染、尿路感染、皮肤软组织感染、生殖道感染、骨和关节感染等。2-乙基己酸为合成头孢噻肟钠的副反应物。乙基己酸是一种化学物质它对健康危害，对皮肤、粘膜有刺激作用。

建立气相色谱法测定注射用头孢噻肟钠中2-乙基己酸的含量。方法：石英毛细管柱；载气：氮气；汽化室温度220℃；进样口温度：200℃；检测器温度250℃；柱温140℃。进样量：1μl，分流比30：1。定量方法：内标峰面积法。2-乙基己酸在0.5～8mg·mL-1范围内呈良好的线性关系（r=0.99996）。2-乙基己酸平均回收率分别为99.1%。结论：本法简便、准确，可用于2-乙基己酸的含量测定。

注射用头孢噻肟钠中2乙基己酸 测试谱图：




2-Ethylhexanoic Acid in Cefotaxime Sodium for Injection
2-Ethylhexanoic Acid in Cefotaxime Sodium for Injection Details:

Name: Capillary Column
Fixing fluid: polyethylene glycol
Specification: 30m*0.25mm*0.25um
Model: PEG-20M

Cefotaxime sodium for injection is a third-generation semi-synthetic cephalosporin with a broader antibacterial spectrum than cefuroxime. It is suitable for pneumonia caused by sensitive bacteria and other lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, and reproductive tract infections. , Bone and joint infections. 2-Ethylhexanoic acid is a side reactant in the synthesis of cefotaxime sodium. Ethylhexanoic acid is a chemical substance that is harmful to health and has a stimulating effect on the skin and mucous membranes.

A gas chromatography method was established to determine the content of 2-ethylhexanoic acid in cefotaxime sodium for injection. Method: quartz capillary column; carrier gas: nitrogen; vaporization chamber temperature 220°C; injection port temperature: 200°C; detector temperature 250°C; column temperature 140°C. Injection volume: 1μl, split ratio 30:1. Quantitative method: internal standard peak area method. 2-Ethylhexanoic acid showed a good linear relationship in the range of 0.5～8mg·mL-1 (r=0.99996). The average recovery rates of 2-ethylhexanoic acid were 99.1%, respectively. Conclusion: This method is simple and accurate, and can be used for the determination of 2-ethylhexanoic acid.

Test spectrum of 2-ethylhexanoic acid in cefotaxime sodium for injection: