HH-624毛细管柱 药用级聚乙烯醇中甲醇和乙酸甲酯测定

名称：毛细管色谱柱

固定相：6% 氰丙基苯基／94% 二甲基聚硅氧烷
极性：弱极性到中等极性固定相
相当于 USP 固定相 G43

型号：HH-624

规格：30m*0.53mm*3.0um

应用：药用辅料聚乙烯醇质量标准甲醇及乙酸甲酯

药用级聚乙烯醇 药典标准CP版医药原料

中文名称:聚乙烯醇
CAS:98002-49-4
英文名称:VINOL 523
分子式:C₂H₄O
分子量:44.05256

聚乙烯醇树脂系列产品系白色固体，外型分絮状、颗粒状、粉状三种；无毒无味、无污染，可在80--90℃水中溶解。其水溶液有很好的粘接性和成膜性；能耐油类、润滑剂和烃类等大多数有机溶剂；具有长链多元醇酯化、醚化、缩醛化等化学性质。

浩瀚色谱（山东）应用技术开发有限公司一种测定聚乙烯醇中甲醇和乙酸甲酯含量的方法，包括溶解、盐析、过滤和测定各单元过程，所述溶解是将聚乙烯醇加入蒸馏水中，聚乙烯醇和蒸馏水的质量比为1：20-30，加热回流的条件下使聚乙烯醇完全溶解得到聚乙烯醇溶液；所述盐析是向所述聚乙烯醇溶液中加入无机盐，无机盐的添加量是聚乙烯醇质量的6-8倍，常温搅拌使聚乙烯醇析出，过滤分离收集滤液；通过气相色谱法测定所述滤液中甲醇和乙酸甲酯的含量。与通用的静态顶空气相色谱法相比，准确性和精密度高，重复性好，操作简便。

药用级聚乙烯醇中甲醇和乙酸甲酯测定 测试谱图：



Determination of methanol and methyl acetate in pharmaceutical grade polyvinyl alcohol
Determination of methanol and methyl acetate in pharmaceutical grade polyvinyl alcohol

Name: Capillary Chromatographic Column

Stationary phase: 6% cyanopropyl phenyl/94% dimethyl polysiloxane
Polarity: weak to medium polarity stationary phase
Equivalent to USP stationary phase G43

Model: HH-624

Specification: 30m*0.53mm*3.0um

Application: Quality standard of polyvinyl alcohol for pharmaceutical excipients, methanol and methyl acetate

Pharmaceutical grade polyvinyl alcohol Pharmacopoeia standard CP version pharmaceutical raw material

Chinese name: polyvinyl alcohol
CAS:98002-49-4
English name: VINOL 523
Molecular formula: C2H4O
Molecular weight: 44.05256

Polyvinyl alcohol resin series products are white solid, with three appearances: flocculent, granular, and powder; non-toxic, odorless, and pollution-free, and can be dissolved in water at 80-90°C. Its aqueous solution has good adhesion and film-forming properties; it can withstand most organic solvents such as oils, lubricants and hydrocarbons; it has chemical properties such as esterification, etherification, and acetalization of long-chain polyols.

Haohan Chromatography (Shandong) Applied Technology Development Co., Ltd. A method for measuring the content of methanol and methyl acetate in polyvinyl alcohol, including dissolving, salting out, filtering and measuring each unit process. The dissolving is adding polyvinyl alcohol to distilled water , The mass ratio of polyvinyl alcohol and distilled water is 1:20-30, and the polyvinyl alcohol is completely dissolved under heating and refluxing conditions to obtain a polyvinyl alcohol solution; the salting out is to add inorganic salt to the polyvinyl alcohol solution. The added amount of salt is 6-8 times the mass of polyvinyl alcohol, the polyvinyl alcohol is precipitated by stirring at room temperature, and the filtrate is collected by filtration; the content of methanol and methyl acetate in the filtrate is determined by gas chromatography. Compared with the general static headspace gas chromatography, it has high accuracy and precision, good repeatability and easy operation.



Determination of methanol and methyl acetate in pharmaceutical grade polyvinyl alcohol Test spectrum: